Psoriasis is a recurrent inflammatory skin disease with strong family tendencies.
This disease can occur at any age and is one of the most common skin ailments in dermatology.
It is estimated that between 5 and 6 million Americans will be afflicted by psoriasis at
some point in their lifetime. For many patients, there appears to be a direct relationship
between increased stress and their psoriasis flare-ups.
Psoriasis often presents itself with large, red, dry, scaling plaques over the elbows, knees,
and scalp. Itching may also be a problem, but is normally not severe. Mild cases may never
have anything more extensive than the above symptoms. In fact, the condition may spontaneously
improve or even disappear, especially in the summer months.
Other patients with psoriasis are not as fortunate. Occasionally, patients with psoriasis may
only see effects on the palms of their hands or soles of their feet. These areas may have
multiple small blisters or pustules and may be extremely resistant to therapy. In more severe
cases, the condition can progress with many small plaques scattered about the body. Large areas
of skin may be covered with plaques and, in rare instances, the entire surface of the skin can
Treatment of Psoriasis and PUVA Therapy
Treatments for psoriasis have improved considerably over the last 30 years. The use of topical
and intralesional corticosteroids represent the mainstay of therapy for mild cases of this
disease. However, when involvement of the skin exceeds 10% of the total surface, topical
therapy can become time consuming, expensive, and less practical. Fortunately, many types of
effective systemic therapies are now more practical and ease the time constraints placed on
One of the easiest forms of therapy for extensive psoriasis is PUVA therapy. Ninety percent
of patients receiving at least 30 of these treatments usually find relief from their disease.
It is important to note, however, that this is not a cure. Maintenance therapy may occasionally
be necessary to remain clear of psoriasis symptoms. As with all systemic therapy, PUVA therapy
is not perfect and there are no guarantees as to a specific patient's response to treatment.
Other forms of systemic therapy include the use of Methotrexate, cyclosporin, retinoids,
hydroxyurea, and many others. At the moment there are probably 50-60 new therapies for psoriasis
under development at this time. Please discuss the therapeutic options for psoriasis with your